Citadelle is a boutique Silicon Valley consulting firm focusing on the intersection of health care, genomics, and big data.

We help firms by designing analytical infrastructure, providing market insights, guiding product definition, and answering questions that need expertise in precision medicine, big data, genomics, drug discovery, analytics and hardware.

Following section presents example work we do for our clients.

Genomics driven Precision Medicine

Petascale research and clinical genomics solutions need to satisfy requirements around data provenance, software stack reproducibility, analysis reproducibility, and meta data mining. Perhaps the most important considerations in addition to data management challenges are high accuracy variant calling and high performance variant data analytics. We help build practical cutting-edge genomics driven healthcare solutions that extract actionable information from oceans of data. 

Security and Privacy

Genome data, like other biometrics such as fingerprints and iris scans, is personally identifiable information (PII). Government regulations are putting these rapidly growing datasets behind stringent regulatory requirements in order to support patient privacy. We help develop best practices for a secure analytical platform, understand concerns around patient privacy, and navigate the emerging regulatory landscape.

Business Growth in Precision Medicine

Precision Medicine Initiative will only add fuel to the existing fast pace of development in biomedical space. For a company to succeed, they need to design with the pace of change in mind. This is not a trivial task in biomedical space where development cycles have traditionally been decades long. We help companies sift through and prioritize issues they will face in this rapidly evolving landscape, both technologically as well as customer facing ones. And we help VCs and angel funders ask the right questions.  

Computational Drug Discovery 

Computational biology methods have become an integral part of exploring the ever challenging space of new drug design. Companies are using a variety of techniques such as molecular dynamics driven protein modeling, molecular mechanics of protein-ligand binding, ligand similarity searching, and protein pocket finding. We help build a hardware and software toolchain for rapid drug discovery that is customized for the specific requirements of your discovery program. 

High Performance and Cloud Computing

We live in a wonderful world of technology where practically anything is possible. However, taking optimal decisions require a deep understanding of the expected evolution in computational workflows and operational costs - both on-premise and Cloud. We can help you develop multi-year budgets, and plan procurements and deployments. We can also help negotiate with vendors.